Publication at Faculty of Physical Education and Sport |
2011
Abstract
There is a common polymorphism (R577X) in ACTN3 gene that results in absence of alpha-actinin-3 in more than one billion people worldwide. Absence of alpha-actinin-3 is not associated with an obvious disease phenotype.
Those who are engaged in sprint or power activities have a lower incidence of alpha-actinin-3 deficiency than the general population. We focused on recently published studies involving frequency evaluations of R577X in different groups of athletes including papers related to possible physiological explanation in this regard.
However, there is a strong association between R577X polymorphism and sprint or power functioning, a complete genetic nature of sprint performance can not be explained by referred polymorphism.