Acute hyperammonemia activates branched-chain amino acid catabolism and decreases their extracellular concentrations: different sensitivity of red and white muscle

Abstract

The article provides evidence that the main cause of decreased concentrations of branched-chain amino acids in extracellular fluid in patients with liver cirrhosis is hyperammonemia.

Keywords

• Ammonia
• branched-chain amino acids
• leucine metabolism
• protein metabolism
• encephalopathy