The Early Effect of Dextran Sodium Sulfate Administration on Carbachol-Induced Short-Circuit Current in Distal and Proximal Colon During Colitis Development

Abstract

The study describes increased responsiveness of colonic epithelium to carbachol after 3 days of dextran sodium sulfate (DSS) administration. DSS was used to induce colitis.

The increase was sensitive to the inhibition of enteric nervous system (by tetrodotoxin) and prostaglandins production (by indomethacin). These results demonstrate that hyporesponsiveness observed in inflamed colon is likely preceded by overstimulation of the ion transport.

Keywords

• cholinergic
• ion transport
• colitis
• distal and proximal colon
• Ussing chamber