Hypokinesia itself causes also negative changes of the support system, increases the risk of osteoporosis and causes other degenerative changes in joints. If cartilage is no longer loaded, there is a breach of metabolism in the deeper layers.
Many negative changes may be substantially eliminated by periodic multilateral activity, appropriate load (alternate medium intensity) stimulates cartilage growth. In this chapter, attention has focused on cartilage and meniscus knee joint, which is living tissue, but have limited opportunities for growth and renewal.