Abstract
In the Ph.D. thesis, potentially cardioprotective effects of deferiprone (an iron chelator) on the model of daunorubicin-induced chronic cardiotoxicity in rabbits and the role of apoptotic cell death in the development of anthracycline cardiotoxicity were studied. Moreover, the attention was pointed on the study of protective effects of clinically used cardioprotectant dexrazoxane against chronic anthracycline cardiotoxicity with a focus on rescue of cardiac myocytes from programmed cell death and oxidative stress.
Furthermore, in this work the dynamic changes in functional, morphological and other parameters in the time-course of anthracycline cardiotoxicity development were also followed. Finally, the outcomes of this Ph.D. thesis provided many novel findings contributing to the identification of mechanisms of anthracycline cardiotoxicity and effective pharmacological cardioprotection.