Study of the liver efflux transporters and cytochrome P450 with respect to variability of drug pharmacokinetics
Abstract
The aim of presented work was to contribute to current understanding of main processes involved in liver drug elimination. Main attention was paid to elucidation of variability in pharmacokinetics of drugs resulting either from drug- or disease-induced alteration of transport proteins and selected enzymes of cytochrome P450 in the liver.
Regarding drug interactions, the work focuses on both induction and inhibition studies in humans as well as in animal models