Abstract
The purpose of the trial was to determine the effect of pharmaceuticals from the SYSADOA group on the rheological properties of the knee joint with osteoarthritis and the subjective perception of these effects by patients. The trial participants were 15 probands (45 - 77 years) with diagnosed osteoarthritis of the knee joint.
They took a preparation containing substances from the SYSADOA group for a period of 13 weeks. The evaluation of the effect of pharmaceuticals was performed by means of the WOMAC index and changes in rheological properties of the knee joint measured on a special apparatus � the knee biorheometer.
The effects were compared after 13 weeks of taking the preparation and subsequently after another 6 weeks without any therapy. According to the WOMAC index there was an improvement in 13 probands out of 15 after 13 weeks (the average value of the index fell from 25.5 to 17.8).
The discontinuation of the preparation did not manifest any significant change the WOMAC index. Using the Wilcoxon test for paired sets a statistically significant difference (i.e. improvement) of the WOMAC index was discovered between the 1st and the 2nd, but also the 1st and the 3rd measurements.
Results of rheological measurement: comparing the 1st and the 3rd measurement, which shows the long-term trend of SYSADOA effects, the rheological properties improved in 10 osteoarthritic knee joints out of 22, there was no change in 8, and it was only in 4 osteoarthritic knee joints out of 22 that the rheological properties worsened.