Bone markers in tumour metastatic disease - what is behind?

Abstract

Bone metastases are osteolytic, mostly. Their patophophysiology is partly explained by Osteoprotegerin-RANKL-RANK interaction.

So called tumour markers are of very limited value; bone markers have high predictive power. Despite the increasing knowledge most of questions remain unanswered

Keywords

• bone markers
• tumour
• metastases