The effects of lactoferrin in a rat model of catecholamine cardiotoxitcity

Abstract

Lactoferrin is recently under intense investigation because of its proposed several pharmacologically positive effects. Lactoferrin premedication reduced some impairment caused by isoprenaline (e.g., a stroke volume decrease, an increase in peripheral resistance and calcium overload).

These positive effects were likely to have been mediated by the positive inotropic effect of lactoferrin and by inhibition of ROS formation due to chelation of free iron. The failure of lactoferrin to provide higher protection seems to be associated with the complexity of catecholamine cardiotoxicity and with its hydrophilic character