Publication at Faculty of Medicine in Hradec Králové |
2007
Abstract
Statins are administered to a wide range of individuals on an empirical basis. Investigation of the phenotype and genotype influences on treatment response will allow a more tailored use of these drugs.
The development and application of new biotechnological methods to study relationship of phenotypes, genotypes and response to statin therapy upon lipoprotein metabolism will be used: i) distribution of statins and its metabolites in serum lipoprotein and cell membranes, ii) vitamin E content in serum and cell membranes, iii) lipoperoxidation formation and antioxidant consumption