Publication at Faculty of Medicine in Hradec Králové |
2005
Abstract
Cognitive deficit is considered to be one of the basic symptoms of schizophrenia. It is associated with the social impairment and the long term outcome of patients with the disorder.
In addition to neuropsychological methods, event-related potentials can be used to study cognitive functions. in patients with schizophrenia was found a deficit in generation of the amplitude changes in slow negative component of evoked responses to be independent of the focused attention and effort that may interfere with neuropsychological testing. The recent accumulation of knowledge on MMN as a possible preattentive measure of cognition supports int potential significance for more precise diagnosis and functional evaluation of schizophrenia.