Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage - initial study for Myasthenia gravis implications

Abstract

Newly prepared compounds were evaluated in vitro on human erythrocyte AChE, three compounds presented promising inhibition of AChE, two compounds were chosen for docking studies.

Keywords

• cholinesterase
• inhibitor
• Myasthenia gravis
• quaternary
• in vitro
• docking