Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease

Abstract

A series of 7-MEOTA analogues was synthesized. Their inhibitory ability was evaluated on recombinant human acetylcholinesterase (hAChE) and plasmatic human butyrylcholinesterase (hBChE).

Three novel compounds showed promising results against hAChE and three compound were potent inhibitors of hBCHE.

Keywords

• acetylcholinesterase
• butyrylcholinesterase
• Alzheimer disease
• tacrine
• 7-MEOTA
• inhibition