Investigation of Orlistat effects on PXR activation and CYP3A4 expression in primary human hepatocytes and human intestinal LS174T cells

Abstract

The paper describes the effects of Orlistat on CYP3A4 gene expression via pregnane X receptor in primary human hepatocytes and human intestinal LS174T cells.

Keywords

• cytochrome P450
• drug interactions
• enzyme induction
• orlistat
• drug metabolism