Substituted N-phenylpyrazine-2-carboxamides: Synthesis and antimycobacterial evaluation

Abstract

Twelve newly prepared pyrazinecarboxamides were evaluated for their antimycobacterial activity against four different Mycobacterium strains and at the Tuberculosis Antimicrobial Acquisition and Coordinating Facility (TAACF, USA) program.

Keywords

• pyrazinecarboxamide synthesis
• in vitro antimycobacterial screening
• lipophilicity
• SAR