Characterization of metabolites of sibutramine in primary cultures of rat hepatocytes by liquid chromatography - ion trap mass spectrometry

Abstract

Biotransformation profile for sibutramine with rat hepatocytes is proposed. Clear enantioselective formation was observed for two hydroxyl derivatives and two glucuronide conjugates.

Keywords

• sibutramine hydrochloride
• rat hepatocytes
• metabolism
• enantiomers
• liquid chromatography - ion trap mass spectrometry
• product ion spectra