Inactivation of the anticancer drugs doxorubicin and oracin by aldo-keto reductase (AKR) 1C3

Abstract

In the present study, we produced recombinant AKR1C3 and provided evidence that this AKR1C3 member catalyzes the inactivation of oracin and doxorubicin with high efficiency

Keywords

• drug metabolism
• chemotherapeutics
• carbonyl reduction
• oracin
• doxorubicin