HPLC-DAD and MS/MS analysis of novel drug candidates from the group of aromatic hydrazones revealing the presence of geometric isomers

Abstract

HPLC DAD and MS/MS methods were employed to investigate the identity and origin of putative impurities of novel aromatic hydrazones, being formed particularly in aqueous environment [12th Meeting on recent developments in pharmaceutical analysis (RDPA 2007); SEP 23-26 2007; Elba, Italy]

Keywords

• geometric isomers
• aroylhydrazones
• HPLC-MS
• HPLC-DAD
• iron chelators