N-benzylsalicylthioamides, a new group of antimicrobial compounds

Abstract

The general antimicrobial activity of N-(benzyl)salicylthioamide, N-(4-chlorobenzyl)salicylthioamide, N-(3,4-dichlorobenzyl)salicylthioamide, N-(4-methylbenzyl)salicyl-thioamide and N-(4-methoxybenzyl)salicylthioamide was evaluated against Staphylococcus aureus 994/93 MRSA, Staphylococcus aureus 134/93 MRSA, Enteroccoccus faecalis 1528 VRE, Mycobacterium vaccae IMET 10670, Mycobacterium smegmatis SG 987, Mycobacterium aurum SB66 and Mycobacterium fortuitum B

Keywords

• N-benzylsalicylthioamides
• antimicrobial activity
• Topliss approach
• QSAR