Aldo-keto reductases (AKR) from the AKR1C subfamily catalyze the carbonyl reduction of the novel anticancer drug oracin in man

Abstract

Three members of the aldo-keto reductase (AKR) superfamily were found and identified to mediate oracin carbonyl reduction in man

Keywords

• aldo-keto reductases
• drug metabolism
• biotransformation
• carbonyl reduction
• stereospecifity
• chemotherapeutics
• oracin