Pentenolide analogues of antifungal butenolides: strategies towards 3,6-disubstituted pyranones and unexpected loss of biological effect

Abstract

Strategies towards the preparation of 3,6-disubstituted pyranones were developed, and the compounds were evaluated for antifungal and cytostatic activity

Keywords

• pentenolides
• lactones
• electrophilic cyclisation
• carbonylation
• stereoselective hydroalumination
• Pd catalysis
• biological activity