Metabolic profiling of a potential antifungal drug, 3-(4-bromophenyl)-5-acetoxymethyl-2,5-dihydrofuran-2-one, in mice urine using high-performance liquid chromatography with photodiode-array and mass spectrometric detections

Abstract

The metabolism of 3-(4-bromophenyl)-5-acetoxymethyl-2,5-dihydrofuran-2-one in mice was studied, and the metabolites were identified using HPLC with two different modes of detection and comparison with standards

Keywords

• incrustoporine derivatives
• 3-(4-Bromophenyl)-5-acetyloxymethyl-2,5-dihydrofuran-2-one (LNO-18-22)
• metabolites in mouse urine
• HPLC with UV PDA, APCI-MS and ESI-MS detection