Parasympathetic regulation of heart rate in rats after 5/6 nephrectomy is impaired despite functionally intact cardiac vagal innervation

Abstract

The data suggest that cardioacceleration in chronic renal failure is caused by central depression of parasympathetic cholinergic outflow to the heart in the presence of functionally intact intrinsic cardiac choli - nergic signalling system.

Keywords

• asymmetric dimethylarginine
• chronic renal failure