Effects of intravenous sulfide during resuscitated porcine hemorrhagic shock

Abstrakt

Controversial data are available on the effects of hydrogen sulfide during hemorrhage. Because the clinical significance of hydrogen sulfide administration in rodents may not be applicable to larger species, we tested the hypothesis whether intravenous Na2S (sulfide) would beneficially influence organ dysfunction during long-term, porcine hemorrhage and resuscitation.

Klíčová slova

• apoptosis
• heart function
• heme oxygenase-1
• hydrogen sulfide
• hypothermia
• inducible nitric oxide synthase
• inflammation
• kidney function
• liver function
• nuclear transcription factor kappa B
• oxidative stress
• suspended animation