Biphasic alveolosquamoid renal carcinoma: a histomorphological, immunohistochemical, molecular genetic, and ultrastructural study of a distinctive morphologic variant of renal cell carcinoma

Abstract

Only a few cases of sarcomatoid renal cell carcinomas (RCCs) with squamous differentiation have been published. We present 2 RCCs exhibiting a hitherto not reported biphasic neoplastic cell population exhibiting a predominantly alveolar architecture where squamoid differentiation was identified in one of the neoplastic cell populations.

None of the tumors showed chromophobe features or any evidence of sarcomatoid transformation.

Keywords

• Kidney
• Renal cell carcinoma
• Biphasic
• Squamous
• Squamoid
• Alveolosquamoid carcinoma
• Comparative genomic hybridization
• Immunohistochemistry
• Ultrastructure