The article summarises diagnostic criteria, entiopathogenesis, clinical symptoms, and management of primary and secondary humoral immunodeficiencies. Humoral immunodeficiencies are connected with higher susceptibility to infections caused by encapsulated bacteria.
Infections of respiratory and gastrointestinal tract have been predominant. There is also a trend to autoimmune complications and allergies in patients with this diagnosis.
The therapy is based on immunoglobulin substitution and targeted antibiotic treatment. Due to earlier diagnosis and better availability of therapeutic options in recent years, the prognosis of patients with primary immunodeficiencies and their quality of life has improved significantly.