Synthesis of 2 '-deoxy-2 '-fluororibo- and 2 '-deoxy-2 ',2 '-difluororibonucleosides derived from 6-(het)aryl-7-deazapurines

Abstract

A series of novel sugar-modified derivatives of cytostatic 6-hetaryl-7-deazapurine ribonucleosides (2'-deoxy-2'-fluororibo- and 2'-deoxy-2',2-difluororibonucleosides) bearing an aryl or hetaryl group in position 6, was prepared and screened for biological activity. The title nucleosides did not show considerable cytostatic or antiviral activity.

Keywords

• nucleosides
• deazapurines
• cytostatics