Diastereoselective Pauson Khand reaction using chiral pool techniques

Abstract

The Pauson-Khand reaction is formal [2+2+1] cycloaddition reaction involving an alkyne, an alkene and carbon monooxide mediated by a hexacarbonyldicobalt komplex to yield cyclopentanones in a single step. Since its discovery many of asymmetric Pauson-Khand reactions have been developed.

Also the chiral pool approach to the asymetric Pauson-Khand reactions has been very popular methodology used up to now.

Keywords

• Pauson-Khand reaction
• diastereoselective
• dicobaltoctacarbonyl-mediated cyclization
• enynes