Publication at Faculty of Medicine in Hradec Králové |
2012
Abstract
Clofarabine is a purine nucleoside analog. Compared to fludorabine and cladribine.
Clofarabine has an increased resistance to deamination and phosphorlysis, and hence bette stability as well as higher afinity to deoxycytidine kinase. This review describes the results of studies with clofarabine alone or combination AraC and/or anthracykline and its role in the treatment of acute myeloid leukemia.