Heparin-binding protein as a biomarker of circulatory failure during severe infections: a report of three cases
2010
Abstract
A review of cases of tropical malaria, leptospirosis and meningococcal sepsis, in which the high serum concentration of heparin-binding protein was associated with circulatory failure. We report 3 cases of disease - leptospirosis, tropical malaria and fulminant meningococcaemia - associated with high serum concentrations of heparin-binding protein (HBP) and haemodynamic instability.
Furthermore, HBP kinetics were observed for the first 3 days in survivors and were correlated with improvement in clinical condition.