Inhibition of the peptidyl-prolyl-isomerase pin1 enhances the responses of acute myeloid leukemia cells to retinoic acid via stabilization of RAR alpha and PML-RAR alpha

Abstract

The peptidyl-prolyl-isomerase Pin1 interacts with phosphorylated proteins, altering their conformation. The retinoic acid receptor RAR alpha and the acute-promyelocytic-leukemia-specific counterpart PML-RAR alpha directly interact with Pin1.

Keywords

• Acute promyelocytic leukemia
• leukocyte alkaline-phosphatase
• receptor-alpha
• signaling pathways
• nuclear receptors