IGF2BP2 and IGF2 genetic effects in diabetes and diabetic nephropathy

Abstrakt

The IGF2BP2 gene is located on chromosome 3q27.2 within a region linked to type 1 diabetes (T1D), type 2 diabetes (120) and diabetic nephropathy (ON). Its protein functionally binds to 5'-UTR of the imprinting IGF2 gene.

The present study aims to evaluate the IGF2BP2-IGF2 genetic effects in diabetes and DN.

Klíčová slova

• Diabetic nephropathy
• insulin-like growth factor 2
• insulin-like growth factor 2 mRNA binding protein 2
• single nucleotide polymorphism
• type 1 diabetes mellitus
• type 2 diabetes mellitus