B-lymphopoiesis gains sensitivity to subsequent inhibition by estrogens during final phase of fetal development

Abstract

Sensitivity of B-lymphopoiesis for suppression by estrogens after sexual maturation appear to occur during the period of late-stage fetal liver hematopoiesis before its migration to the bone marrow.

Keywords

• Stem cells
• B-lymphopoiesis
• Estrogen
• Development
• Fetal liver
• Reprogramming
• hematopoietic stem-cell
• adult bone-marrow
• lymphocyte precursors
• negative regulators
• stage
• identification
• suppression
• progenitors
• deficiency
• pregnancy