Abstract
The goal of this study was to evaluace routinely used biomarkers together with novel laboratory parameters in the diagnosis of infection. In this prospective study, 54 adult patients with bacterial infections were included.
For comparison, 27 patients with viral infections were enrolled. In these patients, white blood cell (WBC) counts, differential blood counts, serum levels of procalcitonin (PCT), IL-1b, IL-6, IL-8, IL-10, IL-12, TNF-a, IFN-c, soluble CD14 (sCD14), heparinbinding protein (HBP), cortisol (Cort), and monocyte surface expression of TLR2, TLR4, HLA-DR, and CD14 were analyzed.
The highest sensitivity and specificity (expressed as the area under the curve [AUC]) for bacterial infection were observed in serum concentration of PCT (0.952), neutrophil and lymphocyte counts (0.852 and 0.841, respectively), and serumlevels of HBP (0.837), IL-6 (0.830), and Cort (0.817). From the novel potential biomarkers, only PCT demonstrated superiority over the routine parameters in the differentiation of