Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and Cyp2e1-null mice

Abstract

Metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and Cyp2e1-null mice

Keywords

• MITOCHONDRIAL PERMEABILITY TRANSITION
• ALCOHOL-MEDIATED INCREASES
• ACUTE LIVER-FAILURE
• OXIDATIVE STRESS
• RAT-LIVER
• INDUCED HEPATOTOXICITY
• CATECHOL METABOLITES
• HEPATIC GLUTATHIONE
• MOUSE HEPATOCYTES
• COVALENT BINDING