Rifampicin-Activated Human Pregnane X Receptor and CYP3A4 Induction Enhance Acetaminophen-Induced Toxicity

Abstract

The study investigated the mechanisms of toxicity in humanized mice treated by rifampicin and acetaminophen. These findings demonstrated that human preganane X receptor is involved in regulation of acetaminphen -induced toxicity through CYP3A4-mediated hepatic metabolism.

Keywords

• HUMAN CYTOCHROME-P450 3A4
• NUCLEAR RECEPTOR
• INDUCED HEPATOTOXICITY
• NULL MICE
• XENOBIOTIC RECEPTOR
• HUMAN-LIVER
• WILD-TYPE
• GLUTATHIONE
• METABOLOMICS
• TRANSFERASE