Metabolomics reveals a novel vitamin E metabolite and attenuated vitamin E metabolism upon PXR activation

Abstract

Metabolomics in genetically modified mice reveals a novel vitamin E conjugates. These metabolites and attenuated vitamin E metabolism could be used as a biomarker of PXR activation.

Keywords

• pregnane X receptor
• pregnenolone 16 alpha-carbonitrile
• carboxyethyl hydroxychroman
• metabolomics
• gamma-CEHC glucoside
• sterol carrier protein 2
• peroxisomal beta-oxidation