Urinary metabolomics in Fxr-null mice reveals activated adaptive metabolic pathways upon bile acid challenge

Abstract

The metabolomic methods of urine in Fxr-null mice revealed activated adaptive metabolic pathways upon bile acid challenge. These results are useful for identification of biomarkers for cholestasis.

Keywords

• adaptive response
• cholic acid
• cortico-sterone
• Cyp3a11
• farnesoid X receptor
• lithocholic acid
• metabolomics
• p-cresol
• FARNESOID-X-RECEPTOR
• LITHOCHOLIC ACID
• NUCLEAR RECEPTOR
• LIVER TOXICITY
• DETOXIFICATION
• ALPHA
• CORTICOSTERONE
• IDENTIFICATION
• ELIMINATION
• OBSTRUCTION