Proteome Mining of Human Follicular Fluid Reveals a Crucial Role of Complement Cascade and Key Biological Pathways in Women Undergoing in Vitro Fertilization

Abstract

Complement inhibition and the presence of C-terminal fragment of perlecan suggested possible links to angiogenesis which is a vital process in folliculogenesis and placental development.

Keywords

• Human follicular fluid
• plasma
• assisted reproduction
• IVF
• proteomics
• biomarkers
• complement cascade
• angiogenesis
• blood coagulation
• controlled ovarian hyperstimulation
• mature human follicles
• mass-spectrometry
• down-syndrome
• factor-h
• identification
• pregnancy
• proteins
• serum
• biomarkers