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Glycol porphyrin derivatives as potent photodynamic inducers of apoptosis in tumor cells.

Publication at First Faculty of Medicine |
2009

Abstract

The design and synthesis of glycol-functionalized porphyrins that contain one to four low molecular weight glycol chains and the comparison of fluorinated and nonfluorinated para derivatives are reported. The ethylene glykol chain at the meta position exhibits a superior efficacy in human breast carcinoma (MDA-MB-231) therapy.