Genome-wide association study for colorectal cancer identifies risk polymorphisms in German familial cases and implicates MAPK signalling pathways in disease susceptibility
2010
Abstract
In this GWAs study, 10 664 genotyped single-nucleotide polymorphisms (SNPs) passed the quality control filtering in 371 German familial CRC patients and 1263 controls, and replication studies were conducted in four additional case-control sets (4915 cases and 5607 controls). We have observed that the risk of CRC increased significantly with an increasing number of risk alleles in seven genes involved in MAPK signalling events.