Serious cutaneous toxicity following ifosfamide, gemcitabine and vinorelbine therapy in a patient with relapsed Hodgkin lymphoma and ichthyosis]
Abstract
Hodgkin lymphoma was histologically proven in a 47-year-old male patient with a long-lasting history of ichthyosis. Patient was treated with six cycles of combined chemotherapy. 15 months after initial treatment the first relapse of Hodgkin lymphoma was confirmed.
Patient was successfully treated with six cycles of chemotherapy followed by radiotherapy. The above mentioned chemotherapies did not cause serious cutaneous toxicity. 4 years after previous therapy the second relapse of Hodgkin lymphoma occurred.
Patient was treated with three cycles of combined chemotherapy: ifosfamide, gemcitabine, vinorelbine and prednisone. This chemotherapy caused neutropenia WHO grade 4 after each cycle and a serious diffuse toxoallergic cutaneous reaction with bullous erythema developed.
Several skin lesions fulfilled criteria for cutaneous WHO grade 3 and 4 toxicity.