Abstract
Aim of the study is to determine the extent of brain impairment in patients with verified systemic lupus erythematosus (SLE) with neuropsychiatric manifestations (NP-SLE) and cerebral vascular events. The study has two parts: one part is retrospective, second part prospective, both are based on the monitoring of SLE patients with strokes from the nationwide register of SLE patients int he Czech republic.