GATA-1 directly regulates p21 gene expression during erythroid differentiation.

Abstract

GATA-1 directly regulates transcription of the p21 gene in both erythroleukemia cells and normal erythroid progenitors. Our findings indicate that p21 is a crucial downstream gene target and effector of GATA-1 during red blood cell terminal differentiation.

Keywords

• p21
• GATA-1
• transcription
• differentiation
• erythroid
• Sp1
• KLF1