Hepcidin, the hormone of iron metabolism, is bound specifically to alpha-2-macroglobulin in blood

Abstract

The work demonstrates, that hepcidin is specificialy bound in human blood by alpha-2-macroglobulin. The affinity constant of the complex was determined and allosteric regulation was demonstrated

Keywords

• Iron metabolism
• hepcidin
• blood
• alpha-2-macroglobulin
• albumin