Abstract
The contemporary era of targeted, so-called "patient-tailored", oncological therapy essentially began upon the discovery of hormonal receptors and targeted clinical use of tamoxifen. Initial clinical use of trastuzumab in combination with chemotherapy in metastatic breast cancer started the era of bioregulatory nonhormonal therapy for breast cancer (12).
Targeted molecular therapy is no longer a mere subject of research but a reality in the clinical practice of breast cancer treatment.