Comparative Effects of Teriparatide and Strontium Ranelate on Bone Biopsies and Biochemical Markers of Bone Turnover in Postmenopausal Women With Osteoporosis
2009
Abstract
In bone biopsies in 29 patients in the teriparatide group and 22 in the SrR group, the mineralization surfaces as a percent of bone surfaces (MS/BS, %) at the endocortical level measured after 6 mo of treatment were 17.22 +/- 3.06% and 9.70 +/- 2.07%, respectively (p = 0.052). The changes in biochemical markers of bone formation confirmed bone-forming activity of teriparatide but not of SrR treatment.
The effects of SrR on bone remodeling and cell activity were modest, indicating that its effects on fracture reduction may be predominantly mediated through a different mechanism than that observed with anabolic or more potent antiresorptive agents.