Abstract
Colorectal cancer (CRC) has been considered to be the most frequent cancer disease based on prevalence rate and mortality rate. The earlier diagnostics provides the better therapy outcomes.
Many new laboratory tests and techniques for early detection of CRC have been developed recently. Not many of the can be used for daily routine clinical practice so far.
The aim of this dissertation thesis was to measure a large spectrum of parameters in patients with early stage of CRC and to evaluate them for routine practice, as they may play a potential regulatory role in cancer development and control process. Some of the parameters are important for prognosis estimate and particularly for therapy monitoring.
Further intensive study of tumor biological activity should result in development of targeted therapy, which should support to establish natural (physiological) equilibrium between substances promoting and inhibiting cellular growth, similarly like in healthy organism.