A consensus protocol for the standardization of cerebrospinal fluid collection and biobanking

Abstract

There is a long history of research into body fluid biomarkers in neurodegenerative and neuroinflammatory diseases. However, only a few biomarkers in CSF are being used in clinical practice.

One of the most critical factors in CSF biomarker research is the inadequate powering of studies because of the lack of sufficient samples that can be obtained in single-center studies.

Keywords

• Multiple-sclerosis patients
• amyloid-beta peptides
• status scale edss
• lumbar puncture
• diagnostic-criteria
• mass-spectrometry
• disability
• disease
• blood
• serum