Abstract
In this paper, we summarize current knowledge on the impact of vascular brain changes and vascular risk factors on the development and course of Alzheimer's disease. The authors discuss the time relation and interactions between vascular and neurohistopathological changes typical for Alzheimer's disease, commenting on possible underlying mechanisms of their origin.
Neuroimaging methods to detect vascular changes in the brain are described; findings of these methods are correlated with an impact on cognitive functions and on the risk of developing Alzheimer's disease reported in the literature. The most common structural changes associated with vascular pathology are white matter lesions and cerebral microbleeds detectable on MRI.